DFG-Sonderforschungsbereich 555 "Komplexe Nichtlineare Prozesse"
Fritz-Haber-Institut der Max-Planck-Gesellschaft, Max-Delbrück-Centrum für molekulare Medizin Berlin, Otto-von-Guericke-Universität Magdeburg, Physikalisch-Technische Bundesanstalt, Technische Universität Berlin
Seminar
"Complex Nonlinear Processes
in Chemistry and Biology"
Honorary Chairman: Gerhard Ertl
Organizers: | M. Bär, H. Engel, M. Falcke, M. Hauser, A. S. Mikhailov, P. Plath, H. Stark |
Address: | Richard-Willstätter-Haus, Faradayweg 10, 14195 Berlin-Dahlem. (Click here for a description how to get there.) |
For information please contact Oliver Rudzick, Tel. (030) 8413 5300, rudzick@fhi-berlin.mpg.de.
Arik Yochelis
(Department of Chemical Engineering, Technion, Haifa, Israel)
Towards Biochemical Control of Physiological Self-Organization
Abstract:
Self-organization of patterns is fundamental to normal and pathological processes in physiology,
examples include signal propagation in neurons, angiogenesis, morphogenesis, cancer, and cardiac
arrhythmia. However, although the molecular and genetic properties acting at microscopic scales
are often suggestive, it is hard to deduce the macroscopic mechanisms, which operate at tissue
levels.
The aim of my talk is to promote and demonstrate the significance of a nonlinear
activator-inhibitor (morphogenetic fields) approach in physiological sciences. The advantage of
such approach is in the potential biochemical robust control of various pathological phenomena.
As a support, I will present how mathematical analysis promoted novel in vitro stem cells based
experiments which considered as central to the notorious vascular calcification phenomenon
(atherosclerosis) [1]. I will also show the significance of an activator-inhibitor approach
in the context of lung development. In particular, the latter provides a plausible mechanistic
explanation for the specific lack of side branching in the transgenic mouse, and strengthens
the claim that morphogen dynamics play an important role in the morphogenesis of branched
structures [2].
[1] A. Yochelis, Y. Tintut, L. L. Demer, and A. Garfinkel, The formation of labyrinths, spots
and stripe patterns in a biochemical approach to cardiovascular calcification,
New J. Phys. 10, 055002 (2008).
[2] Y. Yao, S. Nowak, A. Yochelis, A. Garfinkel, and K. Bostrom, Matrix GLA protein, an
inhibitory morphogen in pulmonary vascular development, J. Biol. Chem. 282, 30131 (2007).
Takao Ohta
(Department of Physics, Kyoto University, Japan)
Dynamics of deformable self-propelled particles [Abstract]
Fred Wolf
(Max-Planck-Institut für Dynamik und Selbstorganisation, Göttingen)
Universality and self-organization in the evolution of the visual cortex [Abstract]
Yasuaki Kobayashi
(Fritz-Haber-Institut der Max-Planck-Gesellschaft)
Design of multi-cluster and desynchronized states in oscillatory
media by nonlinear global feedback [Abstract]
Rudolf Friedrich
(Institut für Theoretische Physik, Westfälische Wilhelms-Universität Münster)
Ratchet effect and the inverse cascade of turbulence
[Abstract] CANCELLED DUE TO ILLNESS!
Ulrich Parlitz
(Drittes Physikalisches Institut, Universität Göttingen)
Nonlinear modeling and data analysis
[Abstract]
last modified: January 11, 2010 / Oliver Rudzick